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流动与智能化合成研究组

科研人员
温正慧
研究员,独立PI

联系方式:

邮箱:zhenghui-wen@ylab.ac.cn

个人简介

甬江实验室研究员,独立课题组长(PI),浙江省海外高层次人才,入选宁波市甬江人才工程。2014年本科毕业于华中科技大学,2017年硕士毕业于中科院大连化物所,师从国内微化工领域先驱陈光文研究员,2022年博士毕业于荷兰阿姆斯特丹大学,师从世界流动化学协会主席Timothy Noël教授。博士毕业后在阿姆斯特丹大学以研究员身份开展研究工作。至今已在Science, Nat. Commun., ACS Cen. Sci., Chem. Sci., ChemsusChem等期刊发表高水平文章数十篇,研究方向包括:自动化合成与AI化学、光催化有机合成、微反应器/流动化学等。

科研成果

1. A. Slattery,+ Z. Wen,+ P. Tenblad,+ J. Sanjosé-Orduna, D. Pintossi, T. den Hartog, T. Noël*. Automated self-optimization, intensification, and scale-up of photocatalysis in flow. Science, 2024, 383, eadj1817. ( (+Co-First) (IF=56.9, Q1)

2. L. Capaldo,+ Z. Wen,+ T. Noël*. A field guide to flow chemistry for synthetic organic chemists. Chem. Sci. 2023, 14, 4230-4247. (+Co-First) (IF=8.4, Hot paper & Pick of the week, Q1). 

3. Z. Wen,+ D. Pintossi,+ M. Nuno, T. Noël*. Membrane-based TBADT recovery as a strategy to increase the sustainability of continuous-flow photocatalytic HAT transformations. Nat. Commun. 2022, 13, 6147. (+Co-First) (IF=16.6, Q1)

4. T. Wan,+ Z. Wen,+ G. Laudadio, L. Capaldo, R. Lammers, J. A. Rincón, P. G. Losada, C. Mateos, M. O. Frederick, R. Broersmad and T. Noël*. Accelerated and Scalable C(sp3)-H Amination via Decatungstate Photocatalysis using a Flow Photoreactor equipped with High-Intensity LEDs. ACS Cent. Sci. 2022, 8, 51–56. (+Co-First) (IF=18.2, Q1)

5. Z. Wen, T. Wan, A. Vijeta, C. Casadevall, L. Buglioni, E. Reisner* and T. Noël*. Photocatalytic C–H Azolation of Arenes using Heterogeneous Carbon Nitride. ChemSusChem. 2021, 14, 5265-5270. (IF=8.4, Q1)

6. Z. Wen, A. Maheshwari, C. Sambiagio, Y. Deng, G. Laudadio, K. V. Aken, Y. Sun, H. P. L. Gemoets, T. Noël*. Optimization of a decatungstate-catalyzed C(sp3)-H alkylation using a continuous oscillatory milli-structured photoreactor. Org. Process Res. Dev. 2020, 24, 2356–2361. (IF=3.4, Q2)

7. Z. Wen, M. Yang, C. Yao, S. Zhao, F. Zhou, G. Chen*. Kinetics study of heterogeneously continuous-flow nitration of trifluoromethoxybenzene. React. Chem. Eng., 2018, 3, 379-387. (IF=3.9, Q2)

8. Z. Wen, F. Jiao, M. Yang, S. Zhao, F. Zhou, G. Chen*. Process development and scale-up of continuous flow nitration of trifluoromethoxybenzene. Org. Process Res. Dev. 2017, 21, 1843-1850. (IF=3.4, Q2)

9. Z. Dong, S. D. A. Zondag, M. Schmid, Z. Wen, T. Noël*. A meso-scale ultrasonic milli-reactor enables gas-liquid-solid photocatalytic reactions in flow. Chem. Eng. J. 2022, 428, 130968. (IF=15.1, Q1)

10. Z. Dong, Z. Wen, F. Zhao, S. Kuhn, T. Noël*. Scale-up of micro- and milli-reactors: An overview of strategies, design principles and applications. Chem. Eng. Sci. X. 2021, 10, 100097. (IF=3.25, Q2) (Top cited paper)

11. S. Zhao, Z. Dong, C. Yao, Z. Wen, G. Chen*, Q. Yuan. Liquid-liquid two-phase flow in ultrasonic microreactors: cavitation, emulsification and mass transfer enhancement. AIChE J. 2018, 64, 1412-1423. (IF=3.7, Q1)

12. F. Zhou, B. Zhang, H. Liu, Z. Wen, K. Wang, G. Chen*. Facile preparation of N-alkyl-2-pyrrolidones in a continuous-flow microreactor. Org. Process Res. Dev. 2018, 22, 504-511. (IF=3.4, Q2)

13. F. Zhou, H. Liu, Z. Wen, B. Zhang, K. Wang, G. Chen*. Toward the efficient synthesis of pseudoionone from citral in a continuous-flow microreactor. Ind. Eng. Chem. Res., 2018, 57, 11288-11298. (IF=4.2, Q2)

 

在研项目

1. 浙江省海外高层次人才引进计划青年人才项目,2025,主持。 
2. 浙江省自然科学基金青年基金项目,2025,主持。 
3. 宁波甬江人才工程青年创新人才项目,2024,主持。 
4. 甬江实验室自主部署项目,2024,主持。